mbt scarpe prezzi To epirubicin -based chemotherap

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To epirubicin-based chemotherapy in the treatment of 516 cases of advanced cancer

Response and tumor changes were observed well in mind the table. Check weekly blood l ~ 2 times, the treatment effect after 2 cycles to determine the near future. Complete summary of the treatment is complete list. General toxic effect of Ha received the World Health Organization (WHO) to develop common indicators and classification to determine:. Fourth,[link widoczny dla zalogowanych], follow-up after treatment, all patients were confirmed by follow-up. Fifth,[link widoczny dla zalogowanych], apply statistical methods of treatment and the factors used test. Results First, the effect of short-term effect of this group of patients in Table 1. Table 1 shows the best efficacy against malignant lymphoma. In 213 cases of non-Hodgkin lymphoma in complete remission 87 down,[link widoczny dla zalogowanych], 99 cases of partial remission. More effective case treatment cycle 1 in the tumor began to shrink, the few drugs markedly after 2 to 3 cycles. 7O cases of breast plague were 8 cases in complete remission, partial remission, 28 down, the effective rate was 51.4; 161 patients with non-small cell lung cancer in complete remission 2 down, partial remission in 71 cases, the effective rate was 45.3; stomach and large intestine cancer, 45 cases, 11 cases were effective, accounting for 24.4%; nasopharyngeal carcinoma in 9 cases. 4 cases of Chinese Internal Medicine March 1997 Volume 36 No. 3 in Table 1 to epirubicin-based chemotherapy in the treatment of patients with advanced cancer 516 cases of recent results Note: 2 cases of gallbladder cancer, ovarian cancer and adenocarcinoma of the parotid 1 down effective rate was 44.4. Second, factors that affect the efficacy of this group of patients on the efficacy of the various factors were analyzed (Table 2), showing that prior treatment had a significant effect on the efficacy or otherwise. 333 cases of patients without treatment response rate was 69.1, while the previous drug treatment through other 175 cases, efficiency is only 48.6. Good general condition before treatment, the patient effects are better than the total amount of epirubicin 250mg was significantly better than the efficacy of low dose patients. However, no effect of gender and age significantly. Third, the adverse reactions adverse reactions in this group of patients in Table 3 to epirubicin-based chemotherapy on bone marrow suppression, especially the white blood cell system is obvious, to limit the dose to improve the main factors. After treatment, white blood cells, hemoglobin and platelets decreased to varying degrees, and 34.1 respectively of 70.6,46,[link widoczny dla zalogowanych],9. White blood cells in 4 cases in this group dropped to 1.0 × 10. / L, but no patient had a fatal because of toxicity. Gastrointestinal reactions are more common, there are varying degrees of nausea and vomiting accounted for 85.7, but the diarrhea, stomatitis less. More than half of patients have varying degrees of hair loss. Intravenous injection of a small number of patients with local stimulation,[link widoczny dla zalogowanych], 2 patients with leakage in the blood vessels outside of the local swelling. 24 cases (4.8%) had alanine aminotransferase (ALT) increased, and 5 (1.0) has a transient creatinine increase, 53 patients (10.7) had mild ECG changes, no heart failure cases. Table 2 for epirubicin chemotherapy in the factors influencing efficacy Note: p <cj. 01, a P <O. 05 Table 3 to epirubicin-based chemotherapy in the treatment of 516 cases of adverse reactions in patients with advanced cancer to discuss Department of anthracycline glycoside in the structure has a base, a sugar side chain and one of ammonia compounds. Since the 60's into the clinic since the status of cancer chemotherapy in more and more important. The first generation of daunorubicin in acute leukemia effect. Second-generation anthracycline doxorubicin as a matter of Taiwan, broad-spectrum antitumor antibiotic, in addition to the effective outside the blood system cancer, breast cancer, thyroid cancer, bone and soft tissue sarcoma, gastrointestinal cancer and lung cancer and so effective. Doxorubicin toxicity, especially myelosuppression and cardiac toxicity more prominent, is to limit the dose to improve the main factors. Doxorubicin and epirubicin as a semi-synthetic derivative of the same molecular weight and adriamycin. The experimental study found that the effect on transplanted tumor equal to or slightly higher with doxorubicin, anti-tumor spectrum are basically the same, but the toxicity of particular therapeutic index and lower cardiac toxicity of doxorubicin, 1.09; epirubicin 1.82. Bonadonna, etc. - in 1993 summarized the clinical application of epirubicin 10 years experience, said: effect of epirubicin and doxorubicin the same, but significantly lower cardiac toxicity, so as to further increase drug dose intensity (DI) create the conditions. As we all know, dose intensity and efficacy of related, and thus extensive ongoing clinical trial. This set of results with similar clinical reports in the literature. Malignant lymphoma, Lopez et al reported that over the last tables doxorubicin alone claim the 20 cases, 15 cases effective. Masaoka et al reported 20 cases, 9 cases of complete remission, partial remission in 3 cases. Perogoh reported 19 cases of advanced non-Hodgkin lymphoma, applications include epirubicin combination chemotherapy regimen can be assessed in 15 patients complete remission in 9 cases. 4 cases of partial remission in 14 cases treated Eridani other non-Hodgkin lymphoma are valid. We replaced the table index doxorubicin doxorubicin group
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